Dec 6 2023 Karolinska Institutet
The use of AI makes it possible for women with a high risk of breast cancer to be identified in mammography screening examinations so that the cancer can be caught earlier. An international research group led from Karolinska Institutet in Sweden can now show that the method is effective in different European countries. The study is published in The Lancet Regional Health – Europe.
An AI-based risk model for evaluating mammographic images is able to identify women with a high risk of breast cancer who might need complementary examinations to improve the possibility of early detection. After testing the method on over 8,500 women in Italy, Spain and Germany, the researchers can now show that the model works well in the different populations.
In current mammography programmes, women are screened over a fixed age (40-74 years old in Sweden) and time interval, often every other year. However, research has shown that the risk of developing breast cancer varies, which means that women would benefit from individualized screening by obtaining a better idea of their personal risk. Risk models have existed for decades and are often based on a woman's family history of breast cancer and lifestyle factors. AI detects tiny changes
By letting a trained AI examine screening images, researchers have developed an entirely new type of risk model based on tiny changes in the images that are far too small for the human eye to register. It's not as simple as traditional models that use a handful of factors such as genes, as there are thousands of factors in the image that are taken into account. The AI is able to find different patterns in these factors, each of which are weak but that the AI can combine. The AI can also give an overall assessment of what is likely to happen in the breast in the future."
Mikael Eriksson, study leader, postdoc researcher at the Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
At present, a large number of women are diagnosed at a late stage and can even develop breast cancer between screenings. The AI-based risk model can be used to determine which women need additional examination as a complement to their normal mammography, so that any tumours can be detected earlier. The current study confirms earlier reports in which the AI-based risk model was able to identify a group of women who had almost seven times the risk of developing breast cancer as the normal population. Individualized screening
"Although about six per cent of the women were high-risk, they are screened today in the same way as low-risk women," says Dr Eriksson. "We think that a specially adapted screening could be more suitable for these women." Related StoriesPotential breakthrough in breast cancer: Five proteins identified as risk markersResearchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomasUCLA researchers win NCI grants to advance liquid biopsy for early detection of cancer
However, the purpose of this study was not to look at clinical use per se but to examine if the method, which had already been evaluated in Sweden and the USA, also works in different mammography programmes around Europe.
"First you develop the model and test it in a slightly more limited population, and then you go on to demonstrate generalisability in other populations, after which you reach a point where you believe that the model works," he continues.
The next phase of the research is to conduct a clinical study in Europe in which women are tested when screened and given different treatments depending on the risk value that the AI model gives them. This method was clinically evaluated in the USA several years ago.
"We're now looking at the possibility of introducing the model in Europe," says Dr Eriksson.
The study was financed by the Swedish Research Council and the Swedish Breast Cancer Association. Mikael Eriksson holds a patent for an image-based risk model for breast cancer licensed to the US company iCAD, Nashua, NH. Source:
Karolinska InstitutetJournal reference:
Eriksson, M., et al. (2023) European validation of an image-derived AI-based short-term risk model for individualized breast cancer screening—a nested case-control study. The Lancet Regional Health – Europe. doi.org/10.1016/j.lanepe.2023.100798.
